Type of cellular connection that minimizes metabolic flows between adjacent cells.
1
Microvillis and zonula occludens were observed on the surface of the differentiated cells under an electron microscope.
2
Most gap junctions between neurons in mammalian retina contain abundant connexin36, often in association with the scaffolding protein zonula occludens-1.
3
The expression and membrane localization of the tight junction proteins zonula occludens-1 and occludin were decreased in alveolar epithelial cells from HIV-1 transgenic rats.
1
Sequestration of CAR in tight junctions may limit virus infection across epithelial surfaces.
2
They create tight junctions with mouse hepatocytes, with no evidence of cell fusion.
3
This isoform of TOCA-1 recruits the actin nucleation-promoting factor N-WASP to tight junctions.
4
JAM-A localizes to tight junctions and contributes to paracellular permeability in polarized epithelia.
5
Adherens junctions are calcium dependent; recent evidence suggests that calcium also affects tight junctions.
1
Proposed roles include maintenance of tight junction barriers, signaling and junction remodeling.
2
PKC-ζ inhibition also attenuated AGE-induced decrease of tight junction proteins in HRMECs.
3
Results showed reversible recovery on the expression of tight junction markers.
4
Proteins responsible for tight junction integrity are upregulated in hypertonic states.
5
The tight junction of epithelial cells excludes macromolecules but allows permeation of ions.
6
Occludin is a transmembrane protein of the tight junction with two extracellular loops.
7
Claudin-1 is a tight junction-associated protein recently shown to be expressed in anaplastic meningiomas.
8
Tissue barrier function is directly mediated by tight junction transmembrane proteins known as claudins.
9
Epithelial barrier function is maintained by tight junction proteins that control paracellular fluid flux.
10
A different mechanism of tight junction disruption in CF versus non-CF epithelia was found.
11
This therapy recovered the tight junction protein and mitigated bacterial translocation and lipopolysaccharides levels.
12
Claudins are cell adhesion proteins thought to mediate cell-cell contacts at the tight junction.
13
Our results support the hypothesis that discrete ion channels are present at the tight junction.
14
Our results suggest that BN-PAGE may be a useful tool in understanding tight junction structure.
15
Results: Mino treatment significantly inhibited IR-induced retinal vascular permeability and disruption of tight junction organization.
16
Moreover, apical MMP9 treatment decreased immunostaining of tight junction proteins suggesting disruption of barrier function.
